New tools are turning hormone data into real-time, actionable insights and opening the door to earlier, more precise interventions in reproductive health.
It will be interesting to see where this goes. The applications to individual women will be huge, but the collective understanding of how our hormones work could fill the current gaps if they are able to develop this technology (not really "if", but when).
Totally agree. This technology could be a game changer reshaping everything from diagnosis to treatment. So much potential! Can’t wait to dig into this more with Anna on the podcast soon.
I absolutely appreciate the concept of continuous hormone monitoring but I worry that it may be a false promise right now. Steroid hormones are extremely tricky to measure and require different methods of isolation and measurement techniques than other molecules (like glucose or protein hormones like LH/FSH). Is there any information on how this company is specifically measuring estradiol (the trickiest of them all)? I couldn't find anything on their website. I am honestly curious about this!
Thanks so much for raising this, Molly. Your comment highlights one of the most important questions in the hormone monitoring space: how do we reliably measure something as elusive as estradiol, especially in real time?
Impli is approaching this challenge using aptamer-based technology in the interstitial fluid (ISF), where hormones like estradiol are free-floating—unlike in blood, where they’re often bound and require separation. It’s still incredibly complex: hormones in ISF are present in very small quantities, so Impli is using sensors that are several magnitudes more sensitive than current immunoassays on the market, along with proprietary algorithms to reduce signal drift and noise.
This is very much frontier science. They are entering first-in-human studies this year, so while the ambition is bold, the team is also grounded in scientific rigor.
We’ll be diving deeper into this and more about what Impli is building on an upcoming episode of the FemmeHealth Founders podcast. Definitely one to watch if you are following this space closely!
sorry, i stopped after reading the woman already had a child and is able to essentially pour thousands of dollars down the drain while still maintaining her lifestyle... this is partly my issue with not being a rich YT woman, i'm sure. and yes, i clicked on the article because continuous hormone monitoring works fill in ENORMOUS gaps for women's health. i won't hold my breath, but i will stay curious on this topic.
It will be interesting to see where this goes. The applications to individual women will be huge, but the collective understanding of how our hormones work could fill the current gaps if they are able to develop this technology (not really "if", but when).
Totally agree. This technology could be a game changer reshaping everything from diagnosis to treatment. So much potential! Can’t wait to dig into this more with Anna on the podcast soon.
I absolutely appreciate the concept of continuous hormone monitoring but I worry that it may be a false promise right now. Steroid hormones are extremely tricky to measure and require different methods of isolation and measurement techniques than other molecules (like glucose or protein hormones like LH/FSH). Is there any information on how this company is specifically measuring estradiol (the trickiest of them all)? I couldn't find anything on their website. I am honestly curious about this!
Thanks so much for raising this, Molly. Your comment highlights one of the most important questions in the hormone monitoring space: how do we reliably measure something as elusive as estradiol, especially in real time?
Impli is approaching this challenge using aptamer-based technology in the interstitial fluid (ISF), where hormones like estradiol are free-floating—unlike in blood, where they’re often bound and require separation. It’s still incredibly complex: hormones in ISF are present in very small quantities, so Impli is using sensors that are several magnitudes more sensitive than current immunoassays on the market, along with proprietary algorithms to reduce signal drift and noise.
This is very much frontier science. They are entering first-in-human studies this year, so while the ambition is bold, the team is also grounded in scientific rigor.
We’ll be diving deeper into this and more about what Impli is building on an upcoming episode of the FemmeHealth Founders podcast. Definitely one to watch if you are following this space closely!
sorry, i stopped after reading the woman already had a child and is able to essentially pour thousands of dollars down the drain while still maintaining her lifestyle... this is partly my issue with not being a rich YT woman, i'm sure. and yes, i clicked on the article because continuous hormone monitoring works fill in ENORMOUS gaps for women's health. i won't hold my breath, but i will stay curious on this topic.